Chemistry Heterocyclic Building Blocks Triazoles 1H-Benzo[D][1,2,3]Triazol-1-Ol

1H-Benzo[D][1,2,3]Triazol-1-Ol

These compounds have the same murcko framework: 1H-benzo[d][1,2,3]triazol-1-ol

Acid-Base Reactions: The hydroxyl group (-OH) can act as a Brønsted-Lowry base, accepting a proton (H+) to form the conjugate acid, or as a Brønsted-Lowry acid, donating a proton to form the conjugate base.
Substitution Reactions: The hydroxyl group (-OH) can undergo substitution reactions. For example, it can be replaced by a halogen or other leaving groups under suitable conditions.
Oxidation-Reduction Reactions: The hydroxyl group can be oxidized to a carbonyl compound (aldehyde or ketone) under strong oxidizing conditions.
Nucleophilic Substitution Reactions: The nitrogen atoms in the triazole ring can act as nucleophiles, undergoing substitution reactions with electrophiles. This can lead to the formation of new bonds at the nitrogen positions.
Ring-Opening Reactions: The triazole ring can potentially undergo ring-opening reactions under specific conditions, especially with strong nucleophiles or electrophiles.
Condensation Reactions: The hydroxyl group can participate in condensation reactions, such as forming esters, ethers, or amides with appropriate reagents.
Metal Complexation: The hydroxyl and nitrogen atoms can coordinate with metal ions, forming metal complexes that may exhibit different reactivity profiles compared to the free molecule.
Tautomerism: The compound may exist in tautomeric forms, where the position of the double bond and the location of hydrogen atoms can change. This can influence its reactivity in different environments.

Further Reading:

Framework+−

(5As,10Br)-2-Phenyl-2,5A,6,10B-Tetrahydro-4H-Indeno[2,1-B][1,2,4]Triazolo[4,3-D][1,4]Oxazin-11-Ium 1-(Phenylsulfonyl)-1H-1,2,4-Triazole 1-Benzyl-1H-1,2,3-Triazole 1-Benzyl-1H-1,2,4-Triazole 1-Methyl-1H-1,2,3-Triazole 1-Methyl-1H-1,2,4-Triazole 1-Methyl-1H-Benzo[D][1,2,3]Triazole 1-Phenethyl-1H-1,2,4-Triazole 1-Phenyl-1H-1,2,3-Triazole 1-Phenyl-1H-1,2,4-Triazole 1H-1,2,4-Triazol-3-Amine 1H-1,2,4-Triazol-5-Amine 1H-Benzo[D][1,2,3]Triazol-1-Ol 2-Bromo-[1,2,4]Triazolo[1,5-A]Pyridine 2-Phenyl-2,5,6,7-Tetrahydropyrrolo[2,1-C][1,2,4]Triazol-4-Ium 2-Phenyl-2H-1,2,3-Triazole 2-Phenyl-2H-Benzo[D][1,2,3]Triazole 2H-1,2,3-Triazole 4-(4-Cyclopropylnaphthalen-1-Yl)-4H-1,2,4-Triazole 4-Phenyl-4H-1,2,4-Triazole 4-Phenyl-6H-Thieno[3,2-F][1,2,4]Triazolo[4,3-A][1,4]Diazepine 4H-1,2,4-Triazole 5-Bromo-1H-1,2,4-Triazole 5-Bromo-1H-Benzo[D][1,2,3]Triazole 5-Fluoro-1H-Benzo[D][1,2,3]Triazole 6-Bromo-[1,2,4]Triazolo[1,5-A]Pyridine 6-Bromo-[1,2,4]Triazolo[4,3-A]Pyridine 8-Bromo-[1,2,4]Triazolo[1,5-A]Pyridine [1,2,4]Triazolo[1,5-A]Pyrazine [1,2,4]Triazolo[1,5-A]Pyridin-2-Amine [1,2,4]Triazolo[4,3-A]Pyridin-3-Ylmethanamine Ethyl 1H-1,2,4-Triazole-3-Carboxylate

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